![]() ![]() ![]() It was also found that BT was closely associated with IBO and the injury of intestinal barrier. Cirrhotic rats with IBO had significantly higher rates of intestinal bacterial and endotoxin translocation, slower intestinal transit time and higher intestinal permeability than those without IBO. Intestinal transit (geometric center ratio) was significantly delayed in cirrhotic rats (0.31 ± 0.06) and further more delayed in cirrhotic rats with BT (0.24 ± 0.06) than these without BT (0.38 ± 0.11). Urinary excretion of 99mTc-DTPA in cirrhotic rats with BT (22.2 ± 7.8) was greater than these without BT (10.5 ± 2.9). RESULTS: Bacterial translocation (BT) and IBO was found in 48% and 80% cirrhotic rats respectively and none in control rats. Bacterial translocation (BT) was assessed by bacterial culture of MLN, liver and spleen, IBO by a jejunal bacterial count of the specific organism, intestinal permeability by determination of the 24-hour urinary 99mTc-DTPA excretion and intestinal transit by measurement of the distribution of 51Cr in the intestine. METHODS: All animals were assessed with variables including bacterial and endotoxin translocation, intestinal bacterial overgrowth, intestinal transit and permeability. ![]() AIM: To investigate the effects of cisapride on intestinal bacterial overgrowth (IBO), bacterial and endotoxin translocation, intestinal transit and permeability in cirrhotic rats. ![]()
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